Samantha Walsh, MLS, MA (She/her/hers)
Manager of Information & Education Services
Did you know that many of the educational sessions offered by your Levy Librarians are recorded and available on our YouTube channel? Whether you can’t make the live session or just need a quick refresh on a topic, these videos are available on-demand to help you navigate library resources & further your research!
Check out these three videos:
Review Types: Selecting the Right Review Methodology for Your Research Question
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Are you overwhelmed with the sheer amount of review types out there in the research literature? Don't understand the difference between systematic and scoping reviews? Recently heard of integrative reviews but are clueless as to what they entail? Join Librarian Carrie Levinson for a 60-minute session on the most popular review types, including literature/narrative, systematic, scoping, integrative, and rapid reviews. Each review type is defined and differentiated from the rest so that you can determine which review is most appropriate for your topic.
Searching the New PubMed
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Launched in 2020, the redesigned PubMed has many features that even experienced PubMed searches may benefit from exploring! Join Librarian Lily Martin as she introduces the new display, navigation, and output features now available. The session then goes beyond new features to provide a refresher on PubMed best practices, including searching and working with search results.
How to Build a Search
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Beginning with an information need and concluding with a comprehensive search query, this quick 30-minute session will give you the tools you need to create an effective search strategy. While we focus on PubMed, the session is designed so that the skills learned may be used on any bibliographic database or search engine. Librarian Samantha Walsh goes over Boolean search operators (AND, OR, NOT), parentheses, asterisks, quotation marks, and using the Search Builder on PubMed's advanced search page to build a robust search strategy.
Each month Levy Library showcases the achievements of Mount Sinai faculty and researchers by highlighting an article and its altmetrics. Altmetrics are alternative measures of impact that capture non-traditional data like abstract views, article downloads, and social media activity. Our altmetrics data is provided by the PlumX platform.
This month we highlight Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia. This article was written in part by Ruben Mylvaganam MD.
ABSTRACT
Some patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) develop severe pneumonia and acute respiratory distress syndrome1 (ARDS). Distinct clinical features in these patients have led to speculation that the immune response to virus in the SARS-CoV-2-infected alveolus differs from that in other types of pneumonia2. Here we investigate SARS-CoV-2 pathobiology by characterizing the immune response in the alveoli of patients infected with the virus. We collected bronchoalveolar lavage fluid samples from 88 patients with SARS-CoV-2-induced respiratory failure and 211 patients with known or suspected pneumonia from other pathogens, and analysed them using flow cytometry and bulk transcriptomic profiling. We performed single-cell RNA sequencing on 10 bronchoalveolar lavage fluid samples collected from patients with severe coronavirus disease 2019 (COVID-19) within 48 h of intubation. In the majority of patients with SARS-CoV-2 infection, the alveolar space was persistently enriched in T cells and monocytes. Bulk and single-cell transcriptomic profiling suggested that SARS-CoV-2 infects alveolar macrophages, which in turn respond by producing T cell chemoattractants. These T cells produce interferon-γ to induce inflammatory cytokine release from alveolar macrophages and further promote T cell activation. Collectively, our results suggest that SARS-CoV-2 causes a slowly unfolding, spatially limited alveolitis in which alveolar macrophages containing SARS-CoV-2 and T cells form a positive feedback loop that drives persistent alveolar inflammation.
View this article profile here!