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Coming in September: Introduction to EndNote
08/22/2018
Angelyn Thornton
No Subjects

Classes have resumed at Icahn School of Medicine at Mount Sinai and that includes the educational offerings at Levy Library!

First up in our series of open classes is Introduction to EndNote. In this class, you will practice using EndNote X9 to collect, organize and maintain a 'library' of references, find and save full-text journal articles, and insert and format references in a MS Word document. The class will also cover searching and exporting citations from PubMed and Scopus and syncing your desktop library with EndNote Online. 

Introduction to EndNote will take place 3:00pm - 4:00pm on September 18th in Annenberg 11-40.

 

REGISTER HERE! 

 

 

Levy Library Welcomes First Year ISMMS Students
08/15/2018
Angelyn Thornton
No Subjects

Earlier in August, Levy Library welcomed the newest cohort of first year students to the Icahn School of Medicine at Mount Sinai to begin their journey toward becoming medical professionals.

 

Our involvement kicked off with an orientation session in which students were able to pick up their print cards, meet some of our librarians and get answers to any questions that they may have about the Mount Sinai Health System Libraries. 

 

Kerry McKee and Chelsea Gizzi ready to meet the new students

 

Info and candy at the ready!

 

Later in the week, students got to meet librarian Samantha Walsh and hear about all the excellent services and resources that the library system has to offer. 

We are so happy to welcome this new class of students and look forward to helping you in your med school journey!

 

Click here for upcoming Levy Library classes and events.

Learn more about our Education and Research Services. 

Article in the Spotlight: August 2018
08/08/2018
Angelyn Thornton
No Subjects

Each month the Levy Library showcases the achievements of Mount Sinai faculty and researchers by highlighting an article and its altmetrics. Altmetrics are alternative measures of impact that capture non-traditional data like abstract views, article downloads, and social media activity.

This month we highlight Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas. This study was written by a team of researchers including Mount Sinai’s John A. Martignetti (Genetics and Genomics), Robert Korst (Thoracic Surgery), and Peter Dottino (Gynecologic Oncology). 

Citation: Cell Reports, 23(1): 239-254.e9. DOI: 10.1016/j.celrep.2018.03.076 Copyright 2018 The Author(s). This is an open access article under the CC BY-NC-ND license. 

 

 

Summary

DNA damage repair (DDR) pathways modulate cancer risk, progression, and therapeutic response. We systematically analyzed somatic alterations to provide a comprehensive view of DDR deficiency across 33 cancer types. Mutations with accompanying loss of heterozygosity were observed in over 1/3 of DDR genes, including TP53 and BRCA1/2. Other prevalent alterations included epigenetic silencing of the direct repair genes EXO5, MGMT, and ALKBH3 in ∼20% of samples. Homologous recombination deficiency (HRD) was present at varying frequency in many cancer types, most notably ovarian cancer. However, in contrast to ovarian cancer, HRD was associated with worse outcomes in several other cancers. Protein structure-based analyses allowed us to predict functional consequences of rare, recurrent DDR mutations. A new machine-learning-based classifier developed from gene expression data allowed us to identify alterations that phenocopy deleterious TP53 mutations. These frequent DDR gene alterations in many human cancers have functional consequences that may determine cancer progression and guide therapy.

 

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