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Levy Library Blog

Article in the Spotlight: September 2020

by Angelyn Thornton on 2020-09-30T12:00:00-04:00 | Comments

Each month Levy Library showcases the achievements of Mount Sinai faculty and researchers by highlighting an article and its altmetrics. Altmetrics are alternative measures of impact that capture non-traditional data like abstract views, article downloads, and social media activity. Our altmetrics data is provided by the PlumX platform

This month we highlight Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19. This article was written in part by Daniel Blanco-MeloRandy Albrecht, PhDJean K Lim, PhDDavid SachsBenjamin Robert tenOever, PhDDavid Sachs MS, and Benjamin Nilsson-Payant, PhD.       

 


 

HIGHLIGHTS

  • SARS-CoV-2 infection induces low IFN-I and -III levels with a moderate ISG response

  • Strong chemokine expression is consistent across in vitroex vivo, and in vivo models

  • Low innate antiviral defenses and high pro-inflammatory cues contribute to COVID-19

 

SUMMARY

Viral pandemics, such as the one caused by SARS-CoV-2, pose an imminent threat to humanity. Because of its recent emergence, there is a paucity of information regarding viral behavior and host response following SARS-CoV-2 infection. Here we offer an in-depth analysis of the transcriptional response to SARS-CoV-2 compared with other respiratory viruses. Cell and animal models of SARS-CoV-2 infection, in addition to transcriptional and serum profiling of COVID-19 patients, consistently revealed a unique and inappropriate inflammatory response. This response is defined by low levels of type I and III interferons juxtaposed to elevated chemokines and high expression of IL-6. We propose that reduced innate antiviral defenses coupled with exuberant inflammatory cytokine production are the defining and driving features of COVID-19.

 

 
Graphical Abstract

 

View the PlumX article profile 


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